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The 33-year-old felt tightness in his calf during the warm-up ahead of day four in the third Test in Brisbane, and left the field after bowling one over in the morning session.
He was sent for scans and Australia say the injury is likely to result in him missing the fourth and fifth Tests in Melbourne and Sydney.
The right-armer missed the second-Test win in Adelaide with a side injury.
He was replaced by Scott Boland, while uncapped duo Sean Abbott and Brendan Doggett were added to the squad.
"He felt it this morning in warm-ups and gave it a good crack," said bowling coach Daniel Vettori.
"It's just unfortunate for him to come back after putting so much effort in after another injury. It was tough on him.
"He's one of the best bowlers in the world and it obviously affects the whole team."
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