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MacDonald, who was making his debut after joining on transfer deadline day, hit the bar with City's third penalty as they lost 4-2 in the shootout.
"No-one ever wants to miss a penalty, no-one ever does it on purpose.
"I've always been one to put myself forward in a shootout - I always feel like I probably can step up and take a penalty.
"To miss, obviously I'm not going to forget about it for a little while, but it's one that I think we all need to sort of forget about, take the positives from the game tonight and take that into the league and I'm sure we'll be absolutely fine."
Exeter earned plaudits as they doggedly kept out a Forest side that brought on the likes of Chris Wood, Morgan Gibbs-White and Elliot Anderson as they tried to score a winner.
But despite being down to 10 men - and having goalscorer Josh Magennis and winger Ilmari Niskanen fill in as makeshift central defenders as extra time wore on - Exeter held out for spot-kicks.
It was a performance which manager Gary Caldwell said he was proud of.
"When we wake up tomorrow we've got so many positives that we can take moving forward," he told BBC Sport after the match.
"Winning football games is really important, but I think at this football club there's a special side to it.
"What we do in terms of the supporter ownership model is remarkable.
"The league we're competing in, to do what we did tonight against a Premier League team, a full house, people backing their team, getting behind the team - I think it's a special football club and I think it's a football club with a great future.
"I will always be disappointed to lose, but sometimes in football you can gain more from what we did today in terms of showing the club off.
"The supporters' behaviour was incredible - the support they gave the team was incredible and the team responded."
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