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The Red Devils will take on ASEAN All Stars in Kuala Lumpur on 28 May before travelling to play Hong Kong two days later.
United will fly to Asia immediately after their final league game of the season at home to Aston Villa on 25 May.
It is thought the trip will generate about $10m (£7.8m).
United's international players will then join up with their national teams the following week.
Ruben Amorim's side will also travel to the United States as part of the Premier League's pre-season tournament between 26 July and 3 August.
United have a significant fan base in Malaysia and Malaysia Airlines is the club's official commercial airline partner. They last played in the country in 2009 and their previous visit to Hong Kong was in 2013.
Last season, Tottenham Hotspur and Newcastle United flew to Australia for a post-season friendly, which was described as "madness" by BBC pundit Alan Shearer.
The increased workload on elite players has been widely discussed this season, with Fifa's expanded Club World Cup and Uefa's larger Champions League format resulting in FA Cup replays being scrapped to try to ease congestion.
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